TCB Publications - Abstract

Markus Dittrich and Klaus Schulten. Zooming in on ATP hydrolysis in F1. Journal of Bioenergetics and Biomembranes, 37:441-444, 2005. (PMC: 1509602)

DITT2005A We summarize our current view of the reaction mechanism in $\mathrm{F_1}$-ATPase as it has emerged from experiment, theory, and computational studies over the last several years. ATP catalysis in the catalytic binding pockets of $\mathrm{F_1}$ takes place without the release of any significant free energy and is efficiently driven by the combined action of two water molecules utilizing a so-called protein relay-mechanism.

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