Highlights of our Work
The hyperactivity of RAS proteins is associated with tumor progression, invasion, and metastasis in many forms of cancer. RAS proteins must directly interact with the membrane to activate their signaling targets, but the complexity and dynamics of such interactions continue to defy experimental characterization. In a multi-institute collaboration, combining NMR with multi-μs MD simulations with NAMD, and neutron reflectometry, we developed for the first time how a membrane-binding protein domain interacts with and penetrates the surface of the cell at full atomic detail. Analysis of the simulations in VMD revealed that the protein adopts multiple forms on the membrane in a lipid-dependent manner. More details can be found in a recent publication in Nature Communications.
Editorials

The Future of Biomolecular Modeling

A 2015 TCBG Symposium brought together scientists from across the Midwest to brainstorm about what's on the horizon for computational modeling. See a summary of what these experts foresee. Read more

The Annals of MDFF

MDFF is a computational method that yields structures of massive biomolecular assemblies at atomic detail, using hybrid experimental data. Now Illinois scientists are applying MDFF to fascinating systems like the ribosome and HIV. By Lisa Pollack. Read more

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Tajkhorshid receives Beckman Institute Vision and Spirit AwardElectrified PeptidesResearch Programmer PositionAI and Molecular Sciences


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    VMD - Visual Molecular Dynamics. Journal of Molecular Graphics, 14:33-38, 1996.   
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