Bagatin, Mariane Cristovao; Suniga Tozatti, Camila Santos; Abiko, Layara Akemi; dos Santos Yamazaki, Diego Alberto; Alves Silva, Priscila Rebeca; Perego, Leonardo Martins; Audi, Elisabeth Aparecida; Vicente Seixas, Flavio Augusto; Basso, Ernani Abicht; Gauze, Gisele de Freitas
Molecular Docking and Panicolytic Effect of 8-Prenylnaringenin in the Elevated T-Maze

The purpose of this study was to investigate the effects of the chronic administration of a racemic mixture of 8-prenylnaringenin (8-PN) on rats submitted to the elevated T-maze (ETM) model of generalized anxiety and panic disorders. The selective serotonin (SERT) reuptake inhibitor fluoxetine was used as a positive control. Rat locomotion was assessed in a circular arena following each drug treatment. The administration of racemic 8-PN for 21d in rats increased one-way escape latencies from the ETM open arm, indicating a panicolytic effect. To evaluate the interactions of 8-PN with monoamine transporters, a docking study was performed for both the R and S configurations of 8-PN towards SERT, norepinephrine (NET) and dopamine transporters (DAT). The application of the docking protocol showed that (R)-8-PN provides greater affinity to all transporters than does the S enantiomer. This result suggests that enantiomer (R)-8-PN is the active form in the in vivo test of the racemic mixture.

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